MTT Researchers

Kenneth Lee Bost, Ph.D.

Kenneth Lee Bost, Ph.D.

704-687-8677
CBES Area of Expertise:

Immune response; Immunomodulatory therapeutics; Diagnostics; Host response to medical devices; Protein manufacturing

 

CBES Area of Interest:

My laboratory focuses on an understanding of the immune response during microbial infection, autoimmunity, and /or inflammation.  Development of protein-based therapeutics or diagnostics to treat immune-based diseases or to detect alterations during pathological responses is one focus of our efforts.


Vinita Singh Chauhan, Ph.D.

Vinita Singh Chauhan, Ph.D.

704-687-8507
CBES Area of Expertise:

Host-pathogen interactions, immune response, pattern recognition receptors in the central nervous system.

CBES Area of Interest:

My research interests include determining the role of the neuropeptide substance P in microbially induced inflammation of the central nervous system.  We seek to understand the role of resident glial cells of the CNS in the initiation and augmentation of neuro-degenerative inflammation and the possibility of using a systemically delivered antagonist to abrogate this inflammation.  In addition to this, I have been involved in recent studies determining the role of Epstein Barr Virus infection in the cancer progression and metastasis.  We have shown exacerbated metastatic disease in mice harboring murine gamma herpes-virus following transplantation of breast cancer cell lines. Since this murine gamma-herpes virus has been used as a model to study EBV infection, the use of transplantable breast tumor lines in mice harboring latent virus will allow us to address questions that could not be easily investigated in patients.


Mark. G. Clemens, Ph.D.

Mark G. Clemens, Ph.D.

704-687-8682
CBES Area of Expertise:

Regulation of liver microcirculation, hepatic metabolic response to infection, application of imaging techniques to research in biology  and engineered liver support systems.

CBES Area of Interest:

Dr. Clemen’s lab specializes in the regulation of liver microcirculation: Role of stress-inducible vasoactive mediators (endothelin, nitric oxide synthase, hydrogen sulfide, sonic hedgehog, heme oxygenase) in altering vascular responsiveness in the liver following oxidative or inflammatory stress. Mechanisms of control of sinusoid perfusion by hepatic stellate cells, especially related to components of phenotypic transformation in response to injury.   His research is also centered around the hepatic metabolic response to infection. Mechanisms of altered carbohydrate metabolism during sepsis, especially related to differentiation between inflammation-induced changes in gene expression and perfusion supply/demand ratio as mediators of decreased gluconeogenesis.   The application of imaging techniques to biological research is another important part of Dr. Clemen’s researchIt uses the In vivo video microscopy for study of liver microcirculation and an application of quantitative fluorescence techniques in the monitoring of cellular processes in intact organs or in vivo. Engineered liver support systems:  Bioengineering Research Partnership.


Gloria, Elliott, Ph.D.

Gloria D. Elliott, Ph.D.

704-687-8365
CBES Area of Expertise:

Stabilization of mammalian cells in the dry or frozen state for long-term storage; determination of molecular mobility in sugar glasses; protein stabilization in ionic liquid formulations.

CBES Area of Interest:

Dr. Elliott's research specialty is experimental thermodynamics with emphasis on the analysis of living systems.  Biopreservation is the major focus of her work, an area that is becoming increasingly important as changes in the environment continue to affect biodiversity.  Dr. Elliott's research group has been investigating the underlying science of non-refrigerated preservation and developing new technology to support this preservation approach.  Applications under investigation include gamete preservation for in vitro fertilization, development of vaccines that can be transported without refrigeration, and the stabilization of biomolecules, cells, and tissues for clinical diagnostic and therapeutic use.


FARHANG FARHANGFAR

Farhang Farhangfar

CBES Area of Expertise:

Cancer research, cancer vaccines, adult stem cells, clinical trial specimen collection and processing

CBES Area of Interest:

Stem cell biology, immunology, cell and developmental biology, and tissue engineering


David M. Foureau, Ph.D.

704-355-2639
CBES Area of Expertise:
CBES Area of Interest:

Biological treatment of skin cancer as well as immune modulation by and against solid tumors


Nathaniel M. Fried, Ph.D.

Nathaniel M. Fried, Ph.D.

704-687-8149
CBES Area of Expertise:

Laser tissue and biomedical optics.

CBES Area of Interest:

His research specialty is in laser-tissue interactions and biomedical optics, specifically the development of new therapeutic and diagnostic applications of lasers in urology, including laser lithotripsy, laser incision of urethral strictures, laser vaporization of the prostate for treatment of BPH, optical imaging of the cavernous nerves in the prostate to preserve erectile function, laser treatment of female stress urinary incontinence, and endoscopic laser application of mid-infrared optical fibers.


Helen E. Gruber, Ph.D.

Helen E. Gruber, Ph.D.

704-355-5665
CBES Area of Expertise:

Growth human disc cells in tissue culture; tissue engineering methods to test disc cell behavior and response to biologics.

 

CBES Area of Interest:

The research underway in our lab focuses upon understanding the biology of the intervertebral disc and biologic therapies for disc degeneration and low back pain.   These research topics are of interest to many physicians and scientists since the aim will be to develop therapies to treat the conditions in their early stages, with the potential to reverse and modify the disease state.  Various approaches are currently underway, including altering the physiology of disc function through growth factor, cellular augmentation, and tissue engineering; these approaches continue our focus on the cellular basis of disc degeneration and low back pain.


Dr. Rueben Howden

704-687-3583
CBES Area of Expertise:

I am interested in molecular recognition as I develop genetics models for cardiovascular function, identifying specific locations where potentially important regulatory proteins expression is important.  In this context, I am very interested in the capabilities of the new IVIS Spectrum imagining system.

Recently, I have begun work on mechanical properties testing of tendon tissue, which sometimes requires customization of the necessary equipment.  Moreover, I have been working on using the same equipment to test the mechanical properties of vascular and cardiac tissue.

CBES Area of Interest:

I have many years experience analyzing large mouse data sets in both mouse cardiovascular physiology and genetics.  Using these techniques I have identified many chromosomal regions that associate with physiological function at baseline and in response to stress.  Furthermore, I have the equipment and expertise to perform mechanical properties testing on tendons, vascular tissue and many other types of tissue samples can be tested. 


Bharat Joshi, Ph.D.

Bharat Joshi, Ph.D.

704-687-8407
CBES Area of Expertise:

Wearable medical systems (mobile and conformal information infrastructure) for measuring and recording patient vital signs and enabling intelligent decision-making strategies.

 

 

CBES Area of Interest:

V. Klibanov, Ph.D.

V. Klibanov, Ph.D.

704-687-2645
CBES Area of Expertise:

Numerical solution of a parabolic inverse problem in optical tomography using experimental data.

CBES Area of Interest:

 Inverse problems for Partial Differential Equations.  Applications to Medical Optical Imaging.


Charles Y. Lee, Ph.D.

Charles Y. Lee, Ph.D.

704-687-8364
CBES Area of Expertise:

Hypothermic machine perfusion preservation of organs for transplantation.

 

CBES Area of Interest:

Research is in the area of improving organ preservation for transplantation.  Currently, the number of patients waiting for transplants is exponentially increasing while the number of transplants remains stagnant.  Our goal is to improve the technology of hypothermic machine perfusion for preservation of donor livers.  There are many aspects to this goal including the preservation of healthy and marginal donor livers.  Our group focuses on three main topics, improving the preservation of healthy livers, recovery of non-heart-beating donor livers, and improving the preservation of fatty livers.


S. Peter Magnusson, DSc

S. Peter Magnusson, DSc

704-687-0863
CBES Area of Expertise:

Structure and function of human tendons.
 

CBES Area of Interest:

The overall focus of my research is gain insight into the structure and function of human tendons as its relates to:  force transmission on a macroscopic and nanoscale level; adaptation to physical activity and inactivity, and responses to various forms of treatment of tendon injury.
 


Ian Marriott, Ph.D.

Ian Marriott, Ph.D.

704-687-8506
CBES Area of Expertise:

Immunology, Cell biology, Physiology

CBES Area of Interest:

Our research focuses on the mechanisms underlying damaging inflammation in brain and bone tissue following infection.  Microglia and astrocytes are the principle non-neuronal cells of the central nervous system (CNS) and play a key role in host defense against invading pathogens.  However, these glial cells may play a far more sinister role by amplifying the effects of inflammation leading to CNS damage. Much work has been devoted to the study of glial involvement during inflammatory diseases such as meningitis and encephalitis, but despite this the nature of the stimuli that initiate and exacerbate the inflammatory activities of these cells remains a mystery.  We are currently investigating the molecular means by which these resident brain cells perceive bacteria and viruses.  Furthermore, we are also determining the ability of the neurotransmitter substance P to exacerbate such inflammatory responses thereby contributing to neurological damage.  In another project, we seek to determine the role of bone-forming osteoblasts in inflammatory bone damage following bone diseases such as osteomyelitis.  Recent studies from my research team suggest that bacterially infected osteoblasts could be a major source of immune mediators that can promote inflammation, white blood cell recruitment and bone loss at sites of infection.


Daniel Alan Nelson, Ph.D.

Daniel Alan Nelson, Ph.D.

704-687-8514
CBES Area of Expertise:

Biochemistry, Cell biology, Proteins

CBES Area of Interest:

When breast cancers metastasize to other organs, treatment becomes more aggressive and the prognosis less hopeful.  Defining the factors that contribute to metastatic disease is therefore an important goal.  Research in our laboratory has utilized a mouse model of breast cancer to demonstrate that a common viral infection greatly increases metastatic disease.  The experimental murine virus that exacerbates breast cancer metastasis is similar to the common human virus, Epstein Barr virus, which causes mononucleosis in some young adults.  Epstein-Barr virus has been suggested as a factor in breast cancer disease however, such an association has been difficult to prove using human patients.  The advantage of the animal model of metastatic breast cancer is that we can clearly demonstrate the ability of the virus to exacerbate the disease.  We have demonstrated that the Epstein-Barr-like virus does not directly cause breast cancer in animals, but greatly increases metastases to other organs once the animals has the disease.  This demonstration will allow us to begin to understand how such a common viral infection might actually cause dissemination of breast cancers throughout the body.  Hopefully, when we more fully understand the mechanisms mediating virus-exacerbated metastatic breast cancers, new therapies might present themselves for limiting such an aggressive disease.


Kenneth Piller, Ph.D.

Kenneth Piller, Ph.D.

704-687-8522
CBES Area of Expertise:

Biotechnology; Protein-based therapeutics, Vaccines and Toleragens, Diagnostic proteins, Transgenic soybeans, Seed-based protein expression platform.

 

CBES Area of Interest:

As co-founder of SoyMeds, Inc., we use a soy-based platform for production of protein-based therapeutics that can be used to prevent, diagnose and treat disease.  We have expressed vaccine antigens (subunit antigens, VLPs, etc), myelin proteins involved with multiple sclerosis, and the only non-cadaver source of human thyroglobulin that could set a new industry standard as a diagnostic.  Soy-derived proteins address many hurdles associated with vaccination and existing therapies (or lack of), including cost, cold chain, long term storage, manufacture and purification, and in addition posses the ability to generate recombinant proteins that are recalcitrant to expression in existing systems.


Dr. Shaoting Zhang

Dr. Shaoting Zhang

704-687-8565
CBES Area of Expertise:

Dr. Zhang's research is on the interface of medical imaging informatics, large-scale visual understanding and machine learning. He is interested in designing robust and scalable data analytics methods for medical image analysis.

CBES Area of Interest:

Dr. Zhang has been working on robust medical image segmentation, large-scale medical image retrieval, decision support systems, and computer-aided diagnosis. He has developed various methods for multiple use cases, including the automated analysis of histopathological images, cardiac motion reconstruction with tagged MRI, and compressed sensing MRI.