Shan Yan, Ph.D.

CBES Area of Interest:

My research group is interested in the molecularmechanisms of genomic integricty maintenance and tumorigenesis. In particular, our laboratory will tackle three crucial issues in maintaining genomic stability, including checkpoint activation, DNA damage repair, and translesion synthesis (TLS), using biochemical, molecular and cell biology approaches. Ultimately, this research program will help to better understand how cells maintain genome stability and to provide novel clues for precancerous detection and cancer therapeutics. Xenopus egg extracts and human cell lines will be used as modelsystems with cutting-edge technologies.

CBES Area of Expertise:

DNA damage response; DNA replication; checkpointactivation; cell cycle regulation